Cell-surface galectin-3 confers resistance to TRAIL by impeding trafficking of death receptors in metastatic colon adenocarcinoma cells

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis and preferentially kills tumor cells by engaging specific glycosylated death receptors, resulting in the internalization of ligand/receptor complexes and recruitment of the initiator caspase-8 to an activation platform...

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Bibliographic Details
Main Authors: Mazurek, N, Byrd, J C, Sun, Y, Hafley, M, Ramirez, K, Burks, J, Bresalier, R S
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2012
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Original Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246527/
https://ncbi.nlm.nih.gov/pubmed/21941373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.123
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