Quantitation of Membrane-Ligand Interactions Using Backscattering Interferometry

Though membrane-associated proteins are ubiquitous within all living organisms and represent the majority of drug targets, a general method for direct, label-free measurement of ligand binding to native membranes has not been reported. Here we show backscattering interferometry (BSI) to be a viable...

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Bibliographic Details
Main Authors: Baksh, Michael M., Kussrow, Amanda K., Mileni, Mauro, Finn, M.G., Bornhop, Darryl J.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246389/
https://ncbi.nlm.nih.gov/pubmed/21399645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.1790
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