Aberrant firing of replication origins potentially explains intragenic nonrecurrent rearrangements within genes, including the human DMD gene

Non-allelic homologous recombination (NAHR), non-homologous end joining (NHEJ), and microhomology-mediated replication-dependent recombination (MMRDR) have all been put forward as mechanisms to explain DNA rearrangements associated with genomic disorders. However, many nonrecurrent rearrangements in...

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Main Authors: Ankala, Arunkanth, Kohn, Jordan N., Hegde, Anisha, Meka, Arjun, Ephrem, Chin Lip Hon, Askree, Syed H., Bhide, Shruti, Hegde, Madhuri R.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2012
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246204/
https://ncbi.nlm.nih.gov/pubmed/22090376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.123463.111
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