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Ultrasensitive detection of rare mutations using next-generation targeted resequencing
With next-generation DNA sequencing technologies, one can interrogate a specific genomic region of interest at very high depth of coverage and identify less prevalent, rare mutations in heterogeneous clinical samples. However, the mutation detection levels are limited by the error rate of the sequen...
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| Main Authors: | , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2012
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3245950/ https://ncbi.nlm.nih.gov/pubmed/22013163 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr861 |
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