Lapatinib Induces Autophagy, Apoptosis and Megakaryocytic Differentiation in Chronic Myelogenous Leukemia K562 Cells

Lapatinib is an oral, small-molecule, dual tyrosine kinase inhibitor of epidermal growth factor receptors (EGFR, or ErbB/Her) in solid tumors. Little is known about the effect of lapatinib on leukemia. Using human chronic myelogenous leukemia (CML) K562 cells as an experimental model, we found that...

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Bibliografiske detaljer
Main Authors: Huang, Huey-Lan, Chen, Yu-Chieh, Huang, Yu-Chuen, Yang, Kai-Chien, Pan, Hsin yi, Shih, Shou-Ping, Chen, Yu-Jen
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245247/
https://ncbi.nlm.nih.gov/pubmed/22216158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029014
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