Δ(12)-prostaglandin J(3), an omega-3 fatty acid–derived metabolite, selectively ablates leukemia stem cells in mice

Targeting cancer stem cells is of paramount importance in successfully preventing cancer relapse. Recently, in silico screening of public gene-expression datasets identified cyclooxygenase-derived cyclopentenone prostaglandins (CyPGs) as likely agents to target malignant stem cells. We show here tha...

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Detalhes bibliográficos
Main Authors: Hegde, Shailaja, Kaushal, Naveen, Ravindra, Kodihalli C., Chiaro, Christopher, Hafer, Kelsey T., Gandhi, Ujjawal H., Thompson, Jerry T., van den Heuvel, John P., Kennett, Mary J., Hankey, Pamela, Paulson, Robert F., Prabhu, K. Sandeep
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245211/
https://ncbi.nlm.nih.gov/pubmed/21967980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-11-317750
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