Gfi1 expressed in bone marrow stromal cells is a novel osteoblast suppressor in patients with multiple myeloma bone disease

Protracted inhibition of osteoblast (OB) differentiation characterizes multiple myeloma (MM) bone disease and persists even when patients are in long-term remission. However, the underlying pathophysiology for this prolonged OB suppression is unknown. Therefore, we developed a mouse MM model in whic...

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Autori principali: D'Souza, Sonia, del Prete, Davide, Jin, Shunqian, Sun, Quanhong, Huston, Alissa J., Kostov, Flavia Esteve, Sammut, Benedicte, Hong, Chang-Sook, Anderson, Judith L., Patrene, Kenneth D., Yu, Shibing, Velu, Chinavenmeni S., Xiao, Guozhi, Grimes, H. Leighton, Roodman, G. David, Galson, Deborah L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2011
Soggetti:
Lymphoid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245209/
https://ncbi.nlm.nih.gov/pubmed/22042697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-04-346775
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