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insomniac and Cullin-3 Regulate Sleep and Wakefulness in Drosophila

In a forward genetic screen in Drosophila, we have isolated insomniac, a mutant that severely reduces the duration and consolidation of sleep. Anatomically-restricted genetic manipulations indicate that insomniac functions within neurons to regulate sleep. insomniac expression does not oscillate in...

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Hlavní autoři: Stavropoulos, Nicholas, Young, Michael W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3244879/
https://ncbi.nlm.nih.gov/pubmed/22196332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2011.12.003
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