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Overlapping and distinct roles of GRK5 in TLR2-, and TLR3-induced inflammatory response in vivo
G-protein coupled receptor kinase-5 (GRK5) is a recently described NFκB regulator in TLR4 signaling pathway. To determine whether the role of GRK5 is MyD88- or TRIF-dependent, we injected wild type and GRK5 knockout mice with Pam3CSK4 (MyD88-dependent TLR1/2 ligand) and Poly(I:C) (TRIF-dependent TLR...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3244557/ https://ncbi.nlm.nih.gov/pubmed/22078319 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellimm.2011.10.019 |
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