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Regulation of lipopolysaccharide-induced inflammatory response and endotoxemia by β-arrestins

β-arrestins are scaffolding proteins implicated as negative regulators of TLR4 signaling in macrophages and fibroblasts. Unexpectedly, we found that β-arrestin-1 (β-arr-1) and −2 knockout (KO) mice are protected from TLR4-mediated endotoxic shock and lethality. To identify the potential mechanisms i...

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Detalhes bibliográficos
Main Authors: Porter, Katie J., Gonipeta, Babu, Parvataneni, Sitaram, Appledorn, Daniel M., Patial, Sonika, Sharma, Deepika, Gangur, Venugopal, Amalfitano, Andrea, Parameswaran, Narayanan
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930123/
https://ncbi.nlm.nih.gov/pubmed/20589830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.22289
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