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Glucose-activated RUNX2 phosphorylation promotes endothelial cell proliferation and an angiogenic phenotype

The runt-related protein-2 (RUNX2) is a DNA-binding transcription factor that regulates bone formation, tumor cell metastasis, endothelial cell (EC) proliferation, and angiogenesis. RUNX2 DNA binding is glucose and cell cycle regulated. We propose that glucose may activate RUNX2 through changes in p...

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Detalhes bibliográficos
Main Authors: Pierce, Adam D., Anglin, Ian E., Vitolo, Michele I., Mochin, Maria T., Underwood, Karen F., Goldblum, Simeon E., Kommineni, Sravya, Passaniti, Antonino
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3244527/
https://ncbi.nlm.nih.gov/pubmed/21913213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.23354
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