A Carrier for Non-Covalent Delivery of Functional Beta-Galactosidase and Antibodies against Amyloid Plaques and IgM to the Brain

BACKGROUND: Therapeutic intervention of numerous brain-associated disorders currently remains unrealized due to serious limitations imposed by the blood-brain-barrier (BBB). The BBB generally allows transport of small molecules, typically <600 daltons with high octanol/water partition coefficient...

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Main Authors: Sarkar, Gobinda, Curran, Geoffry L., Mahlum, Eric, Decklever, Teresa, Wengenack, Thomas M., Blahnik, Anthony, Hoesley, Bridget, Lowe, Val J., Poduslo, Joseph F., Jenkins, Robert B.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3244419/
https://ncbi.nlm.nih.gov/pubmed/22216132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028881
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