Polyvalent DNA Vaccines Expressing HA Antigens of H5N1 Influenza Viruses with an Optimized Leader Sequence Elicit Cross-Protective Antibody Responses

Highly pathogenic avian influenza A (HPAI) H5N1 viruses are circulating among poultry populations in parts of Asia, Africa, and the Middle East, and have caused human infections with a high mortality rate. H5 subtype hemagglutinin (HA) has evolved into phylogenetically distinct clades and subclades...

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Detalhes bibliográficos
Main Authors: Wang, Shixia, Hackett, Anthony, Jia, Na, Zhang, Chunhua, Zhang, Lu, Parker, Chris, Zhou, An, Li, Jun, Cao, Wu-Chun, Huang, Zuhu, Li, Yan, Lu, Shan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3244406/
https://ncbi.nlm.nih.gov/pubmed/22205966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028757
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