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Scalable, enantioselective taxane total synthesis
Taxanes are a large family of terpenes comprising over 350 members, the most famous of which is Taxol (paclitaxel) — a billion-dollar anticancer drug. Here, we describe the first practical and scalable synthetic entry to these natural products via a concise preparation of (+)-taxa-4(5),11(12)-dien-2...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3243931/ https://ncbi.nlm.nih.gov/pubmed/22169867 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchem.1196 |
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