Loss of Trop2 Promotes Carcinogenesis and Features of Epithelial to Mesenchymal Transition in Squamous Cell Carcinoma

Trop2, an oncogenic cell-surface protein under investigation as a therapeutic target, is commonly overexpressed in several epithelial tumor types yet its function in tumor biology remains relatively unexplored. To investigate the role of Trop2 in epithelial carcinogenesis, we generated Trop2(−/−) mi...

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Main Authors: Wang, Jianbo, Zhang, Kaihua, Grabowska, Dorota, Li, Aimin, Dong, Yiyu, Day, Ryan, Humphrey, Peter, Lewis, James, Kladney, Raleigh D., Arbeit, Jeffrey M., Weber, Jason D., Chung, Christine H., Michel, Loren S.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243826/
https://ncbi.nlm.nih.gov/pubmed/21970857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-11-0241
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