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Characterization of membrane protein non-native states. 1. Extent of unfolding and aggregation of rhodopsin in the presence of chemical denaturants

Little is known about the general folding mechanisms of helical membrane proteins. Unfolded, i.e. non-native states, in particular, have not yet been characterized in detail. Here, we establish conditions under which denatured states of the mammalian membrane protein rhodopsin, a prototypic G protei...

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Bibliographic Details
Main Authors: Dutta, Arpana, Tirupula, Kalyan C, Alexiev, Ulrike, Klein-Seetharaman, Judith
Format: Artigo
Language:Inglês
Published: 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243665/
https://ncbi.nlm.nih.gov/pubmed/20575534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100338e
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