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Analysis of the extent of unfolding of denatured insulin-like growth factor.

Insulin-like growth factor (IGF-1) contains three disulfide bonds. In the presence of denaturant and thiol catalyst, IGF-1 shuffles its native disulfide bonds and denatures to form a mixture of scrambled isomers. The composition of scrambled IGF varies under different denaturing conditions. Among th...

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Detalles Bibliográficos
Main Authors: Chang, J. Y., Märki, W., Lai, P. H.
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 1999
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2144389/
https://ncbi.nlm.nih.gov/pubmed/10422834
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