Directionality of individual kinesin-5 Cin8 motors is modulated by loop 8, ionic strength and microtubule geometry

Kinesin-5 motors fulfil essential roles in mitotic spindle morphogenesis and dynamics as slow, processive microtubule (MT) plus-end directed motors. The Saccharomyces cerevisiae kinesin-5 Cin8 was found, surprisingly, to switch directionality. Here, we have examined directionality using single-molec...

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Autori principali: Gerson-Gurwitz, Adina, Thiede, Christina, Movshovich, Natalia, Fridman, Vladimir, Podolskaya, Maria, Danieli, Tsafi, Lakämper, Stefan, Klopfenstein, Dieter R, Schmidt, Christoph F, Gheber, Larisa
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243633/
https://ncbi.nlm.nih.gov/pubmed/22101328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.403
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