Limited availability of ZBP1 restricts axonal mRNA localization and nerve regeneration capacity

Subcellular localization of mRNAs is regulated by RNA–protein interactions. Here, we show that introduction of a reporter mRNA with the 3′UTR of β-actin mRNA competes with endogenous mRNAs for binding to ZBP1 in adult sensory neurons. ZBP1 is needed for axonal localization of β-actin mRNA, and intro...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Donnelly, Christopher J, Willis, Dianna E, Xu, Mei, Tep, Chhavy, Jiang, Chunsu, Yoo, Soonmoon, Schanen, N Carolyn, Kirn-Safran, Catherine B, van Minnen, Jan, English, Arthur, Yoon, Sung Ok, Bassell, Gary J, Twiss, Jeffery L
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243598/
https://ncbi.nlm.nih.gov/pubmed/21964071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.347
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker