Integrin adhesion and force coupling are independently regulated by localized PtdIns(4,5)(2) synthesis

The 90-kDa isoform of the lipid kinase PIP kinase Type I γ (PIPKIγ) localizes to focal adhesions (FAs), where it provides a local source of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P(2)). Although PtdIns(4,5)P(2) regulates the function of several FA-associated molecules, the role of the FA-...

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Detalhes bibliográficos
Main Authors: Legate, Kyle R, Takahashi, Seiichiro, Bonakdar, Navid, Fabry, Ben, Boettiger, David, Zent, Roy, Fässler, Reinhard
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243596/
https://ncbi.nlm.nih.gov/pubmed/21926969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.332
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