Affinity Maturation to Improve Human Monoclonal Antibody Neutralization Potency and Breadth against Hepatitis C Virus

A potent neutralizing antibody to a conserved hepatitis C virus (HCV) epitope might overcome its extreme variability, allowing immunotherapy. The human monoclonal antibody HC-1 recognizes a conformational epitope on the HCV E2 glycoprotein. Previous studies showed that HC-1 neutralizes most HCV geno...

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Bibliographische Detailangaben
Hauptverfasser: Wang, Yong, Keck, Zhen-yong, Saha, Anasuya, Xia, Jinming, Conrad, Fraser, Lou, Jianlong, Eckart, Michael, Marks, James D., Foung, Steven K. H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Microbiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243554/
https://ncbi.nlm.nih.gov/pubmed/22002064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.290783
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