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α-Synuclein Stimulates a Dopamine Transporter-dependent Chloride Current and Modulates the Activity of the Transporter

Dysregulation of dopamine (DA) homeostasis is implicated in neurodegenerative diseases, drug addiction, and neuropsychiatric disorders. The neuronal plasma membrane dopamine transporter (DAT) is essential for the maintenance of DA homeostasis in the brain. α-Synuclein is a 140-amino acid protein tha...

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Detalhes bibliográficos
Main Authors: Swant, Jarod, Goodwin, J. Shawn, North, Ashley, Ali, Ahmad Abdul, Gamble-George, Joyonna, Chirwa, Sanika, Khoshbouei, Habibeh
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243541/
https://ncbi.nlm.nih.gov/pubmed/21990355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.241232
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