c-Jun N-terminal Kinase Regulates Soluble Aβ Oligomers and Cognitive Impairment in AD Mouse Model

Alzheimer disease (AD) is characterized by cognitive impairment that starts with memory loss to end in dementia. Loss of synapses and synaptic dysfunction are closely associated with cognitive impairment in AD patients. Biochemical and pathological evidence suggests that soluble Aβ oligomers correla...

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Autori principali: Sclip, Alessandra, Antoniou, Xanthi, Colombo, Alessio, Camici, Giovanni G., Pozzi, Laura, Cardinetti, Daniele, Feligioni, Marco, Veglianese, Pietro, Bahlmann, Ferdinand H., Cervo, Luigi, Balducci, Claudia, Costa, Cinzia, Tozzi, Alessandro, Calabresi, Paolo, Forloni, Gianluigi, Borsello, Tiziana
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2011
Soggetti:
Molecular Bases of Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243502/
https://ncbi.nlm.nih.gov/pubmed/22033930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.297515
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