Endothelial expression of human ABCA1 in mice increases plasma HDL cholesterol and reduces diet-induced atherosclerosis

The role of endothelial ABCA1 expression in reverse cholesterol transport (RCT) was examined in transgenic mice, using the endothelial-specific Tie2 promoter. Human ABCA1 (hABCA1) was significantly expressed in endothelial cells (EC) of most tissues except the liver. Increased expression of ABCA1 wa...

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Autores principales: Vaisman, Boris L., Demosky, Stephen J., Stonik, John A., Ghias, Mona, Knapper, Cathy L., Sampson, Maureen L., Dai, Cuilian, Levine, Stewart J., Remaley, Alan T.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Biochemistry and Molecular Biology 2012
Materias:
Patient-Oriented and Epidemiological Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243472/
https://ncbi.nlm.nih.gov/pubmed/22039582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M018713
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