Lifetime-based sensing of the hyaluronidase using fluorescein labeled hyaluronic acid

In this report we propose a lifetime-based sensing (LBS) for the detection of hyaluronidase (HA-ase). First, we heavily label hyaluronan macromolecules (HA) with fluorescein amine. The fluorescein labeled HA (HA-Fl) has a weak fluorescence and short fluorescence lifetime due to an efficient self-que...

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Bibliographic Details
Main Authors:	Fudala, Rafal, Mummert, Mark E., Gryczynski, Zygmunt, Rich, Ryan, Borejdo, Julian, Gryczynski, Ignacy
Format:	Artigo
Language:	Inglês
Published:	2011
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3242895/ https://ncbi.nlm.nih.gov/pubmed/22082776 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jphotobiol.2011.10.005
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Lifetime-based sensing of the hyaluronidase using fluorescein labeled hyaluronic acid

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