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Discovery and mechanism of ustekinumab: A human monoclonal antibody targeting interleukin-12 and interleukin-23 for treatment of immune-mediated disorders

Monoclonal antibody (mAb) therapy was first established upon the approval of a mouse antibody for treatment of human acute organ rejection. However, the high incidence of immune response against the mouse mAb restricted therapeutic utility. Development of chimeric, “humanized” and human mAbs broaden...

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Dades bibliogràfiques
Autors principals: Benson, Jacqueline M, Peritt, David, Scallon, Bernard J, Heavner, George A, Shealy, David J, Giles-Komar, Jill M, Mascelli, Mary Ann
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242840/
https://ncbi.nlm.nih.gov/pubmed/22123062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.3.6.17815
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