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The Reduction of SIRT1 in Livers of Old Mice Leads to Impaired Body Homeostasis and to Inhibition of Liver Proliferation

Age declines liver functions, leading to the development of age-associated diseases. A member of the sirtuins family, SIRT1, is involved in the control of glucose homeostasis and fat metabolism. Because aging livers have alterations in glucose and fat metabolism, we examined a possible role of SIRT1...

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Bibliographic Details
Main Authors: Jin, Jingling, Iakova, Polina, Jiang, Yanjun, Medrano, Estela E., Timchenko, Nikolai A.
Format: Artigo
Language:Inglês
Published: 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242815/
https://ncbi.nlm.nih.gov/pubmed/21638299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.24471
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