Application of a Novel Score Test for Genetic Association Incorporating Gene-Gene Interaction Suggests Functionality for Prostate Cancer Susceptibility Regions

AIMS: We introduce an innovative multilocus test for disease association. It is an extension of an existing score test that gains power over alternative methods by incorporating a parsimonious one-degree-of-freedom model for interaction. We use our method in applications designed to detect interacti...

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Autors principals: Ciampa, Julia, Yeager, Meredith, Jacobs, Kevin, Thun, Michael J., Gapstur, Susan, Albanes, Demetrius, Virtamo, Jarmo, Weinstein, Stephanie J., Giovannucci, Edward, Willett, Walter C., Cancel-Tassin, Geraldine, Cussenot, Olivier, Valeri, Antoine, Hunter, David, Hoover, Robert, Thomas, Gilles, Chanock, Stephen, Holmes, Chris, Chatterjee, Nilanjan
Format: Artigo
Idioma:Inglês
Publicat: S. Karger AG 2011
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Original Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242702/
https://ncbi.nlm.nih.gov/pubmed/22086326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000331222
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