Selective Therapeutic Targeting of the Anaplastic Lymphoma Kinase With Liposomal siRNA Induces Apoptosis and Inhibits Angiogenesis in Neuroblastoma

The anaplastic lymphoma kinase (ALK) is a tyrosine kinase receptor that is involved in the pathogenesis of different types of human cancers, including neuroblastoma (NB). In NB, ALK overexpression, or point mutations, are associated with poor prognosis and advanced stage disease. Inhibition of ALK k...

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Detalhes bibliográficos
Main Authors: Di Paolo, Daniela, Ambrogio, Chiara, Pastorino, Fabio, Brignole, Chiara, Martinengo, Cinzia, Carosio, Roberta, Loi, Monica, Pagnan, Gabriella, Emionite, Laura, Cilli, Michele, Ribatti, Domenico, Allen, Theresa M, Chiarle, Roberto, Ponzoni, Mirco, Perri, Patrizia
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242652/
https://ncbi.nlm.nih.gov/pubmed/21829174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.142
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