Development of tissue-engineered models of oral dysplasia and early invasive oral squamous cell carcinoma

BACKGROUND: Current organotypic models of dysplasia and oral squamous cell carcinoma (OSCC) lack the complexity that mimics in vivo tissue. Here we describe a three-dimensional in vitro model of the oral epithelium that replicates tumour progression from dysplasia to an invasive phenotype. METHODS:...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Colley, H E, Hearnden, V, Jones, A V, Weinreb, P H, Violette, S M, MacNeil, S, Thornhill, M H, Murdoch, C
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2011
Schlagworte:
Molecular Diagnostics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242522/
https://ncbi.nlm.nih.gov/pubmed/21989184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.403
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