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Negative Correlation between Expression Level and Evolutionary Rate of Long Intergenic Noncoding RNAs

Mammalian genomes contain numerous genes for long noncoding RNAs (lncRNAs). The functions of the lncRNAs remain largely unknown but their evolution appears to be constrained by purifying selection, albeit relatively weakly. To gain insights into the mode of evolution and the functional range of the...

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Autores principales: Managadze, David, Rogozin, Igor B., Chernikova, Diana, Shabalina, Svetlana A., Koonin, Eugene V.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2011
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242500/
https://ncbi.nlm.nih.gov/pubmed/22071789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gbe/evr116
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