A Map of Minor Groove Shape and Electrostatic Potential from Hydroxyl Radical Cleavage Patterns of DNA

DNA shape variation and the associated variation in minor groove electrostatic potential are widely exploited by proteins for DNA recognition. Here we show that the hydroxyl radical cleavage pattern is a quantitative measure of DNA backbone solvent accessibility, minor groove width, and minor groove...

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Bibliographic Details
Main Authors: Bishop, Eric P., Rohs, Remo, Parker, Stephen C. J., West, Sean M., Liu, Peng, Mann, Richard S., Honig, Barry, Tullius, Thomas D.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3241897/
https://ncbi.nlm.nih.gov/pubmed/21967305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb200155t
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