A novel dendritic cell-based immunization approach for the induction of durable Th1-polarized anti-HER-2/neu responses in women with early breast cancer

Twenty-seven subjects with HER-2/neu over-expressing ductal carcinoma in situ of the breast were enrolled in a neoadjuvant immunization trial for safety and immunogenicity of DC1-polarized dendritic cells (DC1) pulsed with six HER-2/neu promiscuous MHC class II-binding peptides, plus two additional...

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Main Authors: Koski, Gary K., Koldovsky, Ursula, Xu, Shuwen, Mick, Rosemarie, Sharma, Anupama, Fitzpatrick, Elizabeth, Weinstein, Susan, Nisenbaum, Harvey, Levine, Bruce L, Fox, Kevin, Zhang, Paul, Czerniecki, Brian J
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3241864/
https://ncbi.nlm.nih.gov/pubmed/22130160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0b013e318235f512
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