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Imaging guided trials of the angiogenesis inhibitor sunitinib in mouse models predict efficacy in pancreatic neuroendocrine but not ductal carcinoma

Preclinical trials in mice represent a critical step in the evaluation of experimental therapeutics. Genetically engineered mouse models (GEMMs) represent a promising platform for the evaluation of drugs, particularly those targeting the tumor microenvironment. We evaluated sunitinib, an angiogenesi...

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שמור ב:
מידע ביבליוגרפי
Main Authors: Olson, Peter, Chu, Gerald C., Perry, Samuel R., Nolan-Stevaux, Olivier, Hanahan, Douglas
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2011
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3241750/
https://ncbi.nlm.nih.gov/pubmed/22084065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1111079108
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