Nuclear hormone 1α,25-dihydroxyvitamin D(3) elicits a genome-wide shift in the locations of VDR chromatin occupancy

A global understanding of the actions of the nuclear hormone 1α,25-dihydroxyvitamin D(3) (1α,25(OH)(2)D(3)) and its vitamin D receptor (VDR) requires a genome-wide analysis of VDR binding sites. In THP-1 human monocytic leukemia cells we identified by ChIP-seq 2340 VDR binding locations, of which 11...

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Autores principales: Heikkinen, Sami, Väisänen, Sami, Pehkonen, Petri, Seuter, Sabine, Benes, Vladimir, Carlberg, Carsten
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2011
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3241659/
https://ncbi.nlm.nih.gov/pubmed/21846776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr654
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