A polymorphism in the interleukin-4 receptor affects the ability of interleukin-4 to regulate Th17 cells: a possible immunoregulatory mechanism for genetic control of the severity of rheumatoid arthritis

INTRODUCTION: Rheumatoid arthritis (RA) is now suspected to be driven by pathogenic Th17 cells that secrete interleukin (IL)-17 and can be regulated by IL-4. A single-nucleotide polymorphism (SNP), I50V, in the coding region of the human IL-4 receptor (IL-4R) is associated with rapid development of...

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Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Wallis, Susan K, Cooney, Laura A, Endres, Judith L, Lee, Min Jie, Ryu, Jennifer, Somers, Emily C, Fox, David A
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2011
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3241359/
https://ncbi.nlm.nih.gov/pubmed/21294892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3239
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