A polymorphism in the interleukin-4 receptor affects the ability of interleukin-4 to regulate Th17 cells: a possible immunoregulatory mechanism for genetic control of the severity of rheumatoid arthritis

INTRODUCTION: Rheumatoid arthritis (RA) is now suspected to be driven by pathogenic Th17 cells that secrete interleukin (IL)-17 and can be regulated by IL-4. A single-nucleotide polymorphism (SNP), I50V, in the coding region of the human IL-4 receptor (IL-4R) is associated with rapid development of...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Wallis, Susan K, Cooney, Laura A, Endres, Judith L, Lee, Min Jie, Ryu, Jennifer, Somers, Emily C, Fox, David A
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3241359/
https://ncbi.nlm.nih.gov/pubmed/21294892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3239
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars