Juxtamembrane Shedding of Plasmodium falciparum AMA1 Is Sequence Independent and Essential, and Helps Evade Invasion-Inhibitory Antibodies

The malarial life cycle involves repeated rounds of intraerythrocytic replication interspersed by host cell rupture which releases merozoites that rapidly invade fresh erythrocytes. Apical membrane antigen-1 (AMA1) is a merozoite protein that plays a critical role in invasion. Antibodies against AMA...

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Autori principali: Olivieri, Anna, Collins, Christine R., Hackett, Fiona, Withers-Martinez, Chrislaine, Marshall, Joshua, Flynn, Helen R., Skehel, J. Mark, Blackman, Michael J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3240622/
https://ncbi.nlm.nih.gov/pubmed/22194692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002448
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