Combined Exercise and Insulin-Like Growth Factor-1 Supplementation Induces Neurogenesis in Old Rats, but Do Not Attenuate Age-Associated DNA Damage

We have investigated the effects of 2 weeks of insulin-like growth factor-1 (IGF-1) supplementation (5 μg/kg per day) and 6 weeks of exercise training (60% of the maximal oxygen consumption [VO(2) max]) on neurogenesis, DNA damage/repair, and sirtuin content in the hippocampus of young (3 months old...

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Detalhes bibliográficos
Main Authors: Koltai, Erika, Zhao, Zhongfu, Lacza, Zsombor, Cselenyak, Attila, Vacz, Gabriella, Nyakas, Csaba, Boldogh, Istvan, Ichinoseki-Sekine, Noriko, Radak, Zsolt
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2011
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3239321/
https://ncbi.nlm.nih.gov/pubmed/21867412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/rej.2011.1178
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