Treatment of breast cancer cells with DNA demethylating agents leads to a release of Pol II stalling at genes with DNA-hypermethylated regions upstream of TSS

Inactivation of tumor suppressor genes plays an important role in tumorigenesis, and epigenetic modifications such as DNA methylation are frequently associated with transcriptional repression. Here, we show that gene silencing at selected genes with signs of DNA hypermethylation in breast cancer cel...

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Bibliographic Details
Main Authors: Tao, Yongguang, Liu, Shuang, Briones, Victorino, Geiman, Theresa M., Muegge, Kathrin
Format: Artigo
Language:Inglês
Published: Oxford University Press 2011
Subjects:
Gene Regulation, Chromatin and Epigenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3239205/
https://ncbi.nlm.nih.gov/pubmed/21880597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr611
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