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Rational design of a small molecule-responsive intramer controlling transgene expression in mammalian cells

Aptamers binding proteins or small molecules have been shown to be versatile and powerful building blocks for the construction of artificial genetic switches. In this study, we present a novel aptamer-based construct regulating the Tet Off system in a tetracycline-independent manner thus achieving c...

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Main Authors: Ausländer, David, Wieland, Markus, Ausländer, Simon, Tigges, Marcel, Fussenegger, Martin
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3239198/
https://ncbi.nlm.nih.gov/pubmed/21984476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr829
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