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Recombinant interferon alpha can induce rearrangement of T-cell antigen receptor alpha-chain genes and maturation to cytotoxicity in T-lymphocyte clones in vitro.

T-cell receptor genes are found in the germ-line configuration as well as in rearranged forms, as detected in T lymphocytes by different patterns in Southern blot analysis. We have recently shown that cytotoxic T-lymphocyte (CTL) "precursor" clones, in which rearrangements are not detected in the ge...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Chen, L K, Mathieu-Mahul, D, Bach, F H, Dausset, J, Bensussan, A, Sasportes, M
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1986
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC323848/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3487784/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.13.4887
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