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Genetic alteration of the c-myc protooncogene (MYC) in human primary breast carcinomas.

We have studied the genomic organization of the c-myc locus (MYC) from 121 human primary breast carcinomas. Two types of alterations were observed: (i) the c-myc protooncogene appeared to be amplified 2- to 15-fold in 38 (32%) of the carcinoma DNAs and (ii) a non-germ-line c-myc-related fragment of...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Escot, C, Theillet, C, Lidereau, R, Spyratos, F, Champeme, M H, Gest, J, Callahan, R
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1986
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC323837/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3014513/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.13.4834
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