Epigenetic Regulation of Motor Neuron Cell Death through DNA Methylation

DNA methylation is an epigenetic mechanism for gene silencing engaged by DNA methyltransferase (Dnmt)-catalyzed methyl group transfer to cytosine residues in gene-regulatory regions. It is unknown whether aberrant DNA methylation can cause neurodegeneration. We tested the hypothesis that Dnmts can m...

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Bibliographic Details
Main Authors: Chestnut, Barry A., Chang, Qing, Price, Ann, Lesuisse, Catherine, Wong, Margaret, Martin, Lee J.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3238138/
https://ncbi.nlm.nih.gov/pubmed/22090490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1639-11.2011
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