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Evaluation of a UCMK/dCK Fusion Enzyme for Gemcitabine-Mediated Cytotoxicity
While gemcitabine (2′-2′-difluoro-2′-deoxycytidine, dFdC) displays wide-ranging antineoplastic activity as a single agent, variable response rates and poor intracellular metabolism often limit its clinical efficacy. In an effort to enhance dFdC cytotoxicity and help normalize response rates, we crea...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3237957/ https://ncbi.nlm.nih.gov/pubmed/22093835 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2011.11.025 |
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