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Evaluation of a UCMK/dCK Fusion Enzyme for Gemcitabine-Mediated Cytotoxicity

While gemcitabine (2′-2′-difluoro-2′-deoxycytidine, dFdC) displays wide-ranging antineoplastic activity as a single agent, variable response rates and poor intracellular metabolism often limit its clinical efficacy. In an effort to enhance dFdC cytotoxicity and help normalize response rates, we crea...

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Bibliographic Details
Main Authors: Johnson, Adam J., Brown, Melissa N., Black, Margaret E.
Format: Artigo
Language:Inglês
Published: 2011
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3237957/
https://ncbi.nlm.nih.gov/pubmed/22093835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2011.11.025
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