Aging and infection reduce expression of specific BDNF mRNAs in hippocampus

Aging increases the likelihood of cognitive decline after negative life events such as infection or injury. We have modeled this increased vulnerability in aged (24-month-old), but otherwise unimpaired F344xBN rats. In these animals, but not in younger (3-month-old) counterparts, a single intraperit...

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Bibliografiske detaljer
Main Authors: Chapman, Timothy R., Barrientos, Ruth M., Ahrendsen, Jared T., Hoover, Jennifer M., Maier, Steven F., Patterson, Susan L.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3237944/
https://ncbi.nlm.nih.gov/pubmed/21907460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2011.07.015
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