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The enlarged lysosomes in beige(j) cells result from decreased lysosome fission and not increased lysosome fusion
Chediak-Higashi Syndrome is an autosomal recessive disorder that affects vesicle morphology. The Chs1/Lyst protein is a member of the BEACH family of proteins. The absence of Chs1/Lyst gives rise to enlarged lysosomes. Lysosome size is regulated by a balance between vesicle fusion and fission and ca...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3237799/ https://ncbi.nlm.nih.gov/pubmed/21985295 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-0854.2011.01300.x |
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