Use of a DNA Biobank Linked to Electronic Medical Records to Characterize Pharmacogenomic Predictors of Tacrolimus Dose Requirement in Kidney Transplant Recipients

OBJECTIVE: Tacrolimus, an immunosuppressive drug widely prescribed in kidney transplantation, requires therapeutic drug monitoring due to its marked interindividual pharmacokinetic variability and narrow therapeutic index. Previous studies have established that CYP3A5 rs776746 is associated with tac...

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Detalhes bibliográficos
Main Authors: Birdwell, Kelly A., Grady, Ben, Choi, Leena, Xu, Hua, Bian, Aihua, Denny, Josh C., Jiang, Min, Vranic, Gayle, Basford, Melissa, Cowan, James D., Richardson, Danielle M., Robinson, Melanie P., Ikizler, T. Alp, Ritchie, Marylyn D., Stein, C. Michael, Haas, David W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3237759/
https://ncbi.nlm.nih.gov/pubmed/22108237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e32834e1641
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