Cortical GAD(67) deficiency results in lower cannabinoid 1 receptor mRNA expression: Implications for schizophrenia

BACKGROUND: Levels of cannabinoid 1 receptor (CB1R) mRNA and protein, which are expressed most heavily in the cholecystokinin class of GABA neurons, are lower in the dorsolateral prefrontal cortex (DLPFC) in schizophrenia, and the magnitude of these differences is strongly correlated with that for g...

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Autori principali: Eggan, Stephen M., Lazarus, Matthew S., Stoyak, Samuel R., Volk, David W., Glausier, Jill R., Huang, Z. Josh, Lewis, David A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3237751/
https://ncbi.nlm.nih.gov/pubmed/22036037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2011.09.014
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